The Main Street Hotel is located at 203 South Main Street in Yazoo City, Mississippi. The hotel provides 16 guest rooms, making it suitable for small to medium-sized business events. It offers meeting spaces that can accommodate conferences and gatherings, with amenities designed to support business needs. Practical facilities include free public parking on site, which does not require reservations. The hotel features basic business amenities and dining options, along with wellness facilities. Outdoor space is available for breaks or informal meetings. Its central location at the address provided makes it convenient for attendees traveling within Yazoo City.